Nadrich Accident Injury Lawyers is investigating serious injury and wrongful death claims involving Andexxa (andexanet alfa).
Andexxa has been pulled from the market due to an increased risk of thrombosis and thrombosis-related death, according to an FDA safety communication.
Andexxa patients and their families are reporting serious and fatal outcomes such as pulmonary embolism, strokes, blood clots, deep vein thrombosis and death.
Who Is Eligible to File an Andexxa Lawsuit?
You may be eligible to file an Andexxa lawsuit if you received Andexxa in a hospital or emergency setting and later experienced clot-related injuries such as:
- Pulmonary embolism
- Stroke
- Heart attack
- Deep vein thrombosis (DVT)
In addition, families of Andexxa patients who died from clot-related complications may qualify to file a wrongful death lawsuit.
Call our experienced dangerous drug lawyers today for a FREE consultation at (800) 718-4658 or contact us if you or a loved one died or experienced a clot-related injury after receiving Andexxa.
We can help you recover financial compensation for medical bills, lost wages, pain, suffering, wrongful death and more.
Victims of dangerous drugs choose Nadrich Accident Injury Lawyers to handle their claims because:
- We have been holding the manufacturers of dangerous drugs liable for our clients’ injuries since 1990.
- Our extensive experience and resources allow us to take on pharmaceutical giants in court and win.
- We represent dangerous drug victims on a contingency fee basis, meaning we won’t charge you any fee until we win your case and our only fee is a percentage of any money we recover for you.
- Our team is available 24/7 and provides reliable communication.
- We and our legal teams have recovered over $750,000,000 for clients.
Past results do not guarantee future outcomes. All cases are unique and results depend on cases’ specific facts.
Table of Contents
- Andexxa Bloodclot Injury Lawsuit Updates [2026]
- What Is Andexxa?
- Injuries Linked to Andexxa
- What Compensation Can I Get for an Andexxa Bloodclot Claim?
- Who Is Liable for Andexxa Injuries?
- How Long Do I Have to File an Andexxa Injury Lawsuit?
- FAQs
- Contact Nadrich Accident Injury Attorneys Today
Andexxa Bloodclot Injury Lawsuit Updates [2026]
January 15, 2026 Update
The recent withdrawal of Andexxa from the U.S. market has left patients taking the blood-thinning medications Eliquis and Xarelto without a reversal agent to reliably prevent bleeding events.
While other reversal agents exist on the market, they aren’t considered a great fit for the two medications.
Vitamin K works only with drugs similar to warfarin. Praxbind (idarucizumab) is only effective with Pradaxa.
This leaves Kcentra (prothrombin complex concentrate), an emergency reversal agent which is approved only for warfarin, but may be used off-label to treat bleeding which is caused by Pradaxa, Eliquis and Xarelto.
However, Kcentra has been shown to be unreliable by research, and is linked with similar thrombotic event risks as Andexxa, leaving its patients at risk of deep vein thrombosis, pulmonary embolism and stroke.
December 22, 2025 Update
AstraZeneca ceased United States sales and production of Andexxa today after federal drug regulators indicated that the drug’s risk of death and blood clots was too high for the drug to be allowed to stay on the market.
A December 18 FDA safety communication announced that they received postmarketing safety data indicating that the drug’s risks, which include fatal blood clots, outweigh its benefits.
This led to AstraZeneca submitting a request to voluntarily withdraw the drug from the market.
The FDA had required AstraZeneca to do a postmarketing study called the ANNEXA-1 trial.
This trial, which investigated 404 patients, led to major safety findings.
14.6 percent of Andexxa patients in the trial experienced clotting, compared to 6.9 percent of patients who did not receive Andexxa.
2.5 percent of Andexxa patients in the trial died, compared with 0.9 percent of patients who did not receive the drug.
November 21, 2024 Update
An FDA advisory committee met today to talk about results from a trial which was conducted to test the safety and efficacy of Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo).
The meeting involved committee members reviewing efficacy and safety data in order to confirm if the medication has clinical benefit.
What Is Andexxa?
Andexxa is an intravenous medication used to reverse the effects of certain prescription blood thinners in emergency situations.
Andexxa was developed for patients taking factor Xa inhibitor anticoagulants, such as rivaroxaban (Xarelto) and apixaban (Eliquis).
Andexxa works by binding to factor Xa inhibitors in the bloodstream, temporarily blocking their anticoagulant activity and blood thinning effects.
Andexxa is a modified form of human factor Xa that acts as a decoy for factor Xa inhibitors, allowing the body’s natural factor Xa to function in blood clotting.
The drug is typically used in:
- Emergency rooms
- Trauma centers
- Intensive care units
The drug is designed for patients experiencing life-threatening or uncontrolled bleeding.
The FDA granted accelerated approval for Andexxa in 2018 as an emergency reversal agent for patients taking factor Xa inhibitors.
Injuries Linked to Andexxa
Patients and their families have reported serious and potentially fatal complications following the use of Andexxa, including:
- Deep vein thrombosis (DVT)
- Pulmonary embolism (PE)
- Heart attack (due to coronary arteries blocked by blood clots)
- Sudden cardiac death
- Ischemic brain injury or stroke
- Other severe blood clot events
- Death
These events, in some cases, happened within mere days or weeks after receiving Andexxa.
What Compensation Can I Get for an Andexxa Bloodclot Claim?
The value of your claim will vary based on the severity of your injury and the specific circumstances of your case.
Individuals may qualify for financial compensation through an Andexxa lawsuit if they received the reversal agent and later experienced a serious blood clot or clot-related complication.
Factors Which Impact Case Value
Factors which can impact the value of your case include:
Injury Severity
Injuries which are permanent or more long-lasting or severe usually lead to more compensation than temporary or minor ailments.
Liability and Causation
A primary factor is how strong the evidence is linking your injury with Andexxa. A clear link between the harm and the defect is essential.
Quality of Documentation and Evidence
Documents showing AstraZeneca’s knowledge of risks, expert testimony, pharmacy records and detailed medical records are all essential for the building of a strong case.
Manufacturer Misconduct
If AstraZeneca knowingly hid Andexxa’s risks, didn’t adequately test Andexxa, or downplayed its side effects, the case’s value increases due to a potential for punitive damages.
Legal Representation
Experienced lawyers can more effectively navigate complex litigation, negotiate with defendants and their insurers, and collect evidence, maximizing the value of your case.
Medical Expenses
An Andexxa blood clot lawsuit will seek financial compensation for all medical bills you already owe, as well as for the costs of any medical treatment you can be reasonably expected to require in the future.
This includes the costs of things like hospital stays, emergency room visits, surgeries, medications, rehabilitation, physical therapy, doctor visits, medical treatments and more.
Lost Wages
Our legal team can help you recover financial compensation for any wages you were unable to earn because you had to take time off of work due to injuries caused by Andexxa.
Loss of Earning Capacity
Clots blocking blood flow to your brain may cause debilitating injuries such as paralysis or permanent neurological injury.
We can help you recover compensation for the loss or reduction of your earning capacity due to your disability if you have been left disabled by Andexxa.
Pain and Suffering
An Andexxa lawsuit will seek financial compensation for all physical pain, mental suffering, emotional distress and lost quality of life associated with any injuries caused by the drug.
Wrongful Death
Families who lost loved ones due to Andexxa can file a wrongful death lawsuit seeking compensation for:
- Funeral and burial costs
- The medical bills their loved one incurred prior to passing
- The pain and suffering their loved one endured prior to passing
- The loss of their loved one’s love, companionship, spousal benefits, income and household services
Punitive Damages
Punitive damages may be available in an Andexxa lawsuit if it can be proven that AstraZeneca knew that the drug was deadly and deliberately covered up the drug’s serious risks, such as the risk that the drug may cause patients to form blood clots.
Who Is Liable for Andexxa Injuries?
AstraZeneca, Andexxa’s manufacturer, is likely liable for injuries related to the drug.
Andexxa lawsuits are being investigated after the drug was pulled from the market due to safety concerns linking its use to serious clotting complications, including stroke, heart attack, pulmonary embolism, and clot-related deaths.
As of January 2026, legal investigations into Andexxa focus on product liability and wrongful death due to serious complications after its use.
Legal issues include claims that AstraZeneca did not adequately research or warn about thrombotic risks associated with Andexxa.
Lawsuit investigations are now focused on whether Andexxa should never have been introduced or kept on the market, given evidence that it did not effectively reverse bleeding events while increasing the risk of serious injuries, including stroke, heart attack, dangerous blood clots, and death.
Lawsuits against AstraZeneca involve allegations of defective design, failure to warn about risks, and delayed market withdrawal.
Legal claims highlight that Andexxa failed to provide meaningful clinical benefit while exposing patients to significant risks during emergency use.
How Long Do I Have to File an Andexxa Injury Lawsuit?
The general statute of limitations for personal injury in California is two years from the date of injury or death.
The discovery rule can apply to dangerous drug cases. This means that the two year clock starts when the patient or family knew or reasonably should have known that Andexxa caused the injury or death.
The statute of limitations may vary from state to state.
Don’t wait: file a claim as soon as possible. Calling us today for a FREE consultation allows evidence to be preserved, ensures all paperwork is filed on time and gives us the most time possible to build the strongest possible case on your behalf.
FAQs
Why Was Andexxa Removed From the Market?
AstraZeneca confirmed it would withdraw Andexxa from the U.S. market and end all U.S. commercial sales by December 22, 2025, after the FDA expressed concerns about findings from the ANNEXA-I clinical trial.
The ANNEXA-I trial showed that patients treated with Andexxa experienced more than double the rate of blood clots compared to patients in the usual care control arm.
The FDA’s review of data from the ANNEXA-I trial indicated a doubling of the rate of thromboses and thrombosis-related deaths at Day 30 in the Andexxa arm compared with patients receiving usual care.
The FDA determined that the risks of Andexxa outweighed its benefits, leading to its withdrawal from the U.S. market in December 2025.
AstraZeneca requested the withdrawal of Andexxa for commercial reasons, ceasing U.S. sales and manufacturing due to safety issues.
What Is a Thromboembolic Event?
Thromboembolic events happen when blood vessels are blocked by blood clots which have broken free.
These events stop blood flow and can potentially lead to tissue damage or death.
These events are also known as venous thromboembolisms.
There are two kinds of thromboembolic events that can lead to fatal outcomes in patients and can be caused by blood clots:
- Deep vein thrombosis: This happens when blood clots develop in deep veins, often in legs.
- Pulmonary embolism: This happens when a section of a blood clot breaks off, traveling into the lungs. This necessitates medical attention immediately.
How Soon After Taking Andexxa Do Blood Clots Occur?
In some cases, serious blood clots have occurred within three days of receiving Andexxa.
The median time for a blood clot to occur in affected patients was found to be 10 days after receiving the drug.
What Does It Cost to Hire an Andexxa Lawyer?
Our lawyers do not charge upfront or out-of-pocket legal fees.
We are contingency fee lawyers, which means that our only fee is a percentage of the compensation we successfully recover for you.
You will not owe us a single penny out of your own pocket, ever, and you will not owe us anything until we win your case.
Contact Nadrich Accident Injury Attorneys Today
Call us today for a FREE consultation at (800) 718-4658 or contact us if you or a loved one suffered a blood clot or a blood clot-related death after receiving Andexxa.
You may qualify for financial compensation for medical bills, lost wages, loss of earning capacity, pain, suffering, wrongful death and more.
Why Choose Us for Your Andexxa Lawsuit?
- We have been handling dangerous drug claims just like yours since 1990.
- Our team has a proven track record of taking on pharmaceutical giants and winning, thanks to our extensive resources and experience.
- We won’t charge you any fee until we win your case.
- Our team provides clients with reliable communication and 24/7 availability.
- We and our legal teams have recovered in excess of $750,000,000 for clients.
Past results do not guarantee future outcomes. All cases are unique and results depend on cases’ specific facts.
